| Description |
F1 cross between 129 and B6 with Nos3 KO. Mice homozygous
for the Nos3 targeted mutation are viable and fertile. They
have elevated blood pressure that is about 20 mmHg higher
than that seen in normal wildtype siblings. They also show a
decreased heart rate. Female homozygotes are smaller in body
weight than normal wildtype siblings.
Hyperglycemic-euglycemic clamp studies demonstrate that
homozygotes exhibit insulin resistance at the level of the
liver and peripheral tissues.
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