| Official Name |
129S6.Cg-Nos3tm1Unc Ins2+/+/J |
| Common Name |
129S6.Cg-Nos3tm1Unc Ins2+/+/J |
| Description |
Control strain for 129S6.Cg-Nos3 Ins2/J. Mice homozygous for
the Nos3 targeted mutation are viable and fertile. They have
elevated blood pressure that is about 20 mmHg higher than
that seen in normal wildtype siblings. They also show a
decreased heart rate. Female homozygotes are smaller in body
weight than normal wildtype siblings.
Hyperglycemic-euglycemic clamp studies demonstrate that
homozygotes exhibit insulin resistance at the level of the
liver and peripheral tissues.
|