Donald McClain

Personal Information
Title Professor
Expertise None Selected
Institution University of Utah
Data Summary
TypeCount
Grants/SubContracts 1
Progress Reports 3
Publications 2
Protocols 2
Committees 0

ANIMAL MODELS OF DIABETIC CARDIOVASCULAR COMPLICATIONS
Grant Number: 1U01HL070525-01

Abstract: The University of Utah is seeking to become one of the Units of the Mouse Models of Diabetic Complications Consortium. We will focus our Unit on the development and refinement of mouse models that will elucidate the pathogenesis of cardiac and vascular disease in diabetes. These models will allow us to test treatment and preventive strategies and will contribute to our knowledge of the specific genetic alterations that lead to cardiovascular dysfunction in diabetes. The strengths that we bring to the Consortium are expertise in mouse genetic engineering, cardiovascular phenotyping, metabolic analyses, and mouse genomics. We are already studying various mouse models of altered nutrient flux and altered nutrient sensing in the heart, which have given novel insight into the pathogenesis of diabetic heart disease. These models will be validated and we will extend our studies by developing mouse models with altered nutrient flux and signal transduction in the vascular endothelium. We have in place multiple facilities and analytic techniques that will allow us to study the mouse cardiovascular system from isolated myocytes or endothelial cells to the intact heart in vivo and in vitro. Cardiovascular function will be assessed in terms of substrate, metabolite and ion fluxes and signal transduction in isolated myocytes, endothelial cells and intact hearts. Physiological assessment of glucose homeostasis, blood pressure, and cardiac function will be performed in vivo. Gene expression changes will be assessed using high throughput screening assays. In most cases, funds from the NIH will be used to extend capabilities and core facilities that are already in place at the University and apply them to the study of diabetic complications. This is exemplified by the University of Utah Mouse Genome Center that will give us access to their expertise in high throughput DNA sequencing, robotic microarray analysis, and bioinformatics. Once models are developed we will be able to efficiently phenotype these and other models, use them to test treatments, and study the effects of modifiers such as hypertension, inflammation and dyslipidemia. Our commitment will be to share these models, data and technologies with the research community to aid in the battle against diabetes and its complications.


Institution: University of Utah
201 PRESIDENTS CIRCLE
ROOM 201
Salt Lake City, UT
Fiscal Year:2001
Department:
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Progress Reports

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Annual Reports

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Title YearTypeOptions
McClain, Donald (2004)
2004Annual Report
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McClain, Donald (2005)
2005Annual Report
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McClain, Donald (2006)
2006Annual Report
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