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University of Wisconsin-Madison
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Defining Host-Microbiome Interctions in Diabetic Wound Healing
Chronic non-healing wounds, such as diabetic foot ulcers, arise when normal tissue repair processes are interrupted. These types of wounds are associated with severe morbidity and diminished quality of life. Further, the microbiome of chronic wounds is highly complex and diverse, comprising bacteria and fungi from both unaffected skin and the environment. Current treatment strategies include sharp debridement of wound tissue, aiming to both reduce microbial burden and stimulate cellular regeneration by inducing an acute wound. However, the mechanisms underlying this response are poorly characterized. Understanding how the microbiome modulates host responses associated with tissue repair may lead to novel diagnostic markers to predict healing outcomes. In this pilot study we propose to employ dual transcriptome profiling (RNA-seq) of the host and microbiome to simultaneously characterize host and microbial gene expression in response to debridement. Our goal is to identify molecular signatures associated with cellular responses to promote healing or microbial signatures associated with impaired wound healing.
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Defining Host-Microbiome Interctions in Diabetic Wound Healing (Kalan, Lindsay)
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Year: 2019; Items: 1
Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy.
Kalan LR, Meisel JS, Loesche MA, Horwinski J, Soaita I, Chen X, Uberoi A, Gardner SE, Grice EA
Cell host & microbe
, 2019 (25), 641 - 655.e5
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The DiaComp Steering Committee is the governing body of the consortium. The principle function of this committee is to guide the scientific direction of the consortium. This is accomplished by creating various subcommittees necessary to advance the scientific goals and providing guidance to the broader complications research community. Policies for the consortium are developed through consultation with the
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The DiaComp Wound Healing Committee has the principal function of furthering the mission of the consortium with regard to diabetic wound healing.
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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