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Charles Powell
Personal Information
Title
Associate Professor
Expertise
Uropathy
Institution
Indiana University-Purdue University-Indianapolis
ORCID
https://orcid.org/0000-0003-2667-6706
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Data Summary
Type
Count
Grants/SubContracts
1
Progress Reports
1
Publications
5
Protocols
0
Committees
2
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Progress Reports
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Progression of Diabetic Cystopathy in the Ossabaw Pig Using Bladder Monitor
Patients suffering from diabetes often have significant bladder complications, called diabetic cystopathy. This is diagnosed by clinical symptoms (LUTS, urinary incontinence, urinary retention) and bladder pressure measurements, called a urodynamic study. Unfortunately there are no methods to detect these changes at an early stage nor to measure progression over time. This is due to lack of a good animal model for diabetic cystopathy, and lack of technology to measure bladder pressure in-vivo over long periods of time. It is hypothesized that the diabetic bladder in the Ossabaw metabolic pig develops elevated storage pressure over time and this contributes to Lower Urinary Tract Symptoms (LUTS). A novel, ultrasound powered wireless bladder pressure measurement device can be implanted and will serve to measure pressures accurately over time to help explore this animal model. It is possible early detection will lead to early intervention and it may be possible to prevent this complication. Aim #1: We will document progression of diabetic cystopathy in the Ossabaw metabolic pig model through use of a novel ultrasound powered wireless implanted device to measure bladder pressure daily over 6 months. Bladder pressures will be compared to those measured in lean pigs (controls). Aim #2: The Ossabaw pig will be demonstrated as a valid animal model for the development of diabetic cystopathy. At the beginning and end of the 6 month study period a formal urodynamic study will be performed on the anesthetized pig to determine 1. Change in anesthetic bladder capacity (mL), 2. Increase in number of episodes of detrusor overactivity 3. Changes in bladder compliance. Serum creatinine and Blood Urea Nitrogen (BUN) content will also be assessed, as will fasting serum glucose (mg/dL) and glycosylated hemoglobin (Hgb A1c) as a measure of severity of diabetes. Bladder biopsies will also be taken. Aim #3: The investigators will demonstrate that the novel, ultrasound powered wireless bladder pressure sensor can accurately measure pressure over time, will not malfunction, and will not migrate out of the bladder or into the lumen of the bladder.
Progress Reports
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Progression of Diabetic Cystopathy in the Ossabaw Pig Using Bladder Monitor (Powell, Charles)
12/11/2015
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Publication
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Submitted By
PubMed ID
Status
Year: 2016; Items: 2
An Universal packaging technique for low-drift implantable pressure sensors.
Kim A, Powell CR, Ziaie B
Biomedical microdevices
, 2016 (18), 32
Submitted Externally
26945864
Published
Conditional Electrical Stimulation in Animal and Human Models for Neurogenic Bladder: Working Toward a Neuroprosthesis.
Powell CR
Current bladder dysfunction reports
, 2016 (11), 379 - 385
Powell, Charles
27920880
Published
Year: 2014; Items: 2
An implantable pressure sensing system with electromechanical interrogation scheme.
Kim A, Powell CR, Ziaie B
IEEE transactions on bio-medical engineering
, 2014 (61), 2209 - 2217
Powell, Charles
24800754
Published
Is the Diabetic Bladder a Neurogenic Bladder? Evidence from the Literature.
Powell CR
Current bladder dysfunction reports
, 2014 (9), 261 - 267
Powell, Charles
30899338
Published
Year: 2013; Items: 1
Neuromodulation for Neurogenic Bladder.
Powell CR
Current bladder dysfunction reports
, 2013 (8), 282 - 288
Powell, Charles
30899337
Published
No uploaded documents found.
No protocols found.
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Steering Committee
The DiaComp Steering Committee is the governing body of the consortium. The principle function of this committee is to guide the scientific direction of the consortium. This is accomplished by creating various subcommittees necessary to advance the scientific goals and providing guidance to the broader complications research community. Policies for the consortium are developed through consultation with the
External Evaluation Committee
Uropathy
The DiaComp Uropathy Committee has the principal function of furthering the mission of the consortium with regard to diabetic complications of the lower genitourinary tract.
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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