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Publication

Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK.

Authors Ix JH, Sharma K Submitted By Kumar Sharma on 3/24/2010 Status Published Journal Journal of the American Society of Nephrology : JASN Year 2010 Date Published 3/1/2010 Volume : Pages 21(3) : 406 - 412 PubMed Reference 20150538 Abstract Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD). Recent studies identify mechanisms common to both diseases linked through an interorgan communication orchestrated by fetuin-A and adiponectin. In liver and kidney, the energy sensor 5'-AMP activated protein kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity.

Complications
All Complications Bioinformatics Bone Cardiomyopathy Cardiovascular Gastro-Intestinal (GI) Nephropathy Neuropathy & Neurocognition Pediatric Endocrinology Retinopathy Uropathy Wound Healing

Genes
Symbol Description Map3k14 mitogen-activated protein kinase kinase kinase 14 Adipoq adiponectin, C1Q and collagen domain containing