| Phenotype Description |
Mice homozygous for the Sod2 targeted mutation die within 21
days after birth. They exhibit severe wasting and are
clearly much smaller, weaker,and less coordinated than their
wildtype and heterozygous littermates. Homoyzotes exhibit
several novel pathogenic phenotypes including severe anemia,
degeneration of neurons in the basal ganglia and brainstem,
progressive motor disturbances, and myocardial injury.
|