| Official Name |
B6.Cg(SJL)-Tg(Nes-cre)1Kln/J |
| Common Name |
B6.Cg(SJL)-Tg(Nes-cre)1Kln/J |
| Description |
These transgenic mice express Cre recombinase under the
control of the rat nestin promoter and enhancer. Mice that
are hemizygous for the transgenic insert are viable,
fertile, normal in size and do not display any gross
physical or behavioral abnormalities. Initial studies
utilizing a reporter strain carrying a beta galactosidase
transgene whose expression is dependent on Cre-mediated
recombination indicate that cre is primarily expressed in
the central and peripheral nervous system with a few
isolated kidney and heart cells also expressing activity.
The donating investigator indicates that Cre recombinase
activity is present in nervous tissue by embryonic day 11.
The transgene insertion location is on Chromosome 12, as
determined by FISH analysis.
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