| Species |
M. musculus |
| Official Name |
FVB.Cg-Ins2Akita Nr1h4tm1Gonz/J |
| Common Name |
FVB.FXR-/- Akita |
| Description |
Mice that are homozygous for the targeted Nr1h4 allele are
viable, fertile, normal in size and do not display any gross
physical or behavioral abnormalities. No Nr1h4 protein
product is detected in liver tissue although an aberrant
transcript appears to be generated. Homozygous mice display
a proatherogenic serum lipoprotein profile characterized by
elevated levels of serum and hepatic cholesterol and
triglycerides. Serum bile acids are also elevated. When fed
a diet supplemented with 1% cholic acid, severe wasting,
hypothermia and increased mortality is observed. Wildtype
mice fed a similar diet display no ill effects. Levels of
fecal bile excretion are reduced in homozygotes. This strain
includes the Akita mutation in the Insulin 2 gene.
|
| Development Status |
Breeding ongoing |
| Creation Method |
congenic |
| Phenotype Description |
Mice that are homozygous for the targeted Nr1h4 allele are
viable, fertile, normal in size and do not display any gross
physical or behavioral abnormalities. No Nr1h4 protein
product is detected in liver tissue although an aberrant
transcript appears to be generated. Homozygous mice display
a proatherogenic serum lipoprotein profile characterized by
elevated levels of serum and hepatic cholesterol and
triglycerides. Serum bile acids are also elevated. When fed
a diet supplemented with 1% cholic acid, severe wasting,
hypothermia and increased mortality is observed. Wildtype
mice fed a similar diet display no ill effects. Levels of
fecal bile excretion are reduced in homozygotes.
|