||Mice homozygous for the Nos3 targeted mutation are viable
and fertile. They have elevated blood pressure that is about
20 mmHg higher than that seen in normal wildtype siblings.
They also show a decreased heart rate. Female homozygotes
are smaller in body weight than normal wildtype siblings.
Hyperglycemic-euglycemic clamp studies demonstrate that
homozygotes exhibit insulin resistance at the level of the
liver and peripheral tissues.