| Description |
Historical reports indicate DBA/1J and DBA/1LacJ mice
immunized with type II collagen develop a severe
polyarthritis mediated by an autoimmune response. Recent
in-house studies suggest that the response to collagen
induction in the DBA/1LacJ strain is not as robust as
indicated by earlier studies. Arthritis models such as
B10.RIII-H2r H2-T18b/(71NS)SnJ (Stock No. 000457) and
BUB/BnJ (Stock No. 000653) can be used as alternatives to
DBA/1LacJ. Similar to the human condition, mice with
collagen-induced arthritis display synovitis and erosions of
cartilage and bone. In addition, susceptibility in both
humans and mice is linked to the expression of specific MHC
class II molecules. DBA/1 mice show a low susceptibility to
developing atherosclerotic aortic lesions (20 to 350 um2
atherosclerotic aortic lesions/aortic cross-section)
following 14 weeks on an atherogenic diet (1.25%
cholesterol, 0.5% cholic acid and 15% fat).
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