| Description |
This strain is a polygenic model for type 1 diabetes.
Diabetes in NOD/ShiLtJ mice is characterized by insulitis, a
leukocytic infiltration of the pancreatic islets. Marked
decreases in pancreatic insulin content occur in females at
about 12 weeks of age and several weeks later in males.
Consequently, plasma glucose levels increase to greater than
250mg/dl.
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