| Description |
C57BL/6J mouse where the thromboxane A2 receptor gene has
been knocked out. The insertion of a PGK-neo cassette into
exon 2 disrupted sequence encoding the third transmembrane
domain. Though Northern blot analysis identified several
aberrant transcripts in homozygous mutant mice, no normal
transcript was detected. Binding assays using a labeled
thromboxane agonist indicated an absence of functional
receptors in both thymocytes and renal sections obtained
from homozygous mutant mice
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