DiaComp :: Strain

129S6-Ins2^Akita/+ Gt(ROSA)26Sor^{tm1(Jak2)Bro/+} Tg(Nphs2-Cre)

Summary

Data Summary

Species	M. musculus
Official Name	129S6-Ins2^Akita/+ Gt(ROSA)26Sor^{tm1(Jak2)Bro/+} Tg(Nphs2-Cre)
Common Name	129S6-Ins2^Akita/+ Gt(ROSA)26Sor^{tm1(Jak2)Bro/+} Tg(Nphs2-Cre)
Description	A flox-stop-flox-Jak2 gene cassette was knocked into the Gt(ROSA)26 locus. Mice also have the Akita mutation in Ins2 with a transgene containing the Cre recombinase driven by the nephrosis 2 homolog, podocin (human) promoter. All animals are heterozygous wild type at each locus.
Development Status	Phenotyping ongoing
Creation Method	knockin
Background	129S6/SvEv
Breeding Type	intercross

Type	Count
Investigators	1
Genomics - Modifications	3
Genomics - Transgenes	1
Models	1

Investigators

Name	Institution
Frank Brosius	University of Arizona

Genomic Information

Gene	Allele 1	Allele 2	Protocol
Ins2	point mutation - transition	wild	Not Specified
Gt(ROSA)26Sor	knockin (lox)	wild	Not Specified
Jak2	knockin (lox)	wild	Not Specified

Enhancer	Promoter	Gene	Copies
Not Specified	Nphs2	CRE	Not Specified

Models

Complication	Strain	Diabetes Type	Status	Investigators
All Complications	129S6-Ins2^Akita/+ Gt(ROSA)26Sor^{tm1(Jak2)Bro/+} Tg(Nphs2-Cre)	Type I	Phenotyping Ongoing	Brosius, Frank

Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:

Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255

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