DiaComp :: Member Profile

Frank Brosius

Personal Information

Title	Professor
Expertise	Nephropathy
Institution	University of Arizona
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Data Summary

Type	Count
Grants/SubContracts	1
Progress Reports	8
Presentations	8
Publications	36
Protocols	6
Committees	1

Progress Reports

No funding program application progress reports found.

Annual Reports


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Title	Year	Type
Brosius, Frank (2004)	2004	Annual Report
Brosius, Frank (2005)	2005	Annual Report
Brosius, Frank (2006)	2006	Annual Report
Brosius, Frank (2007)	2007	Annual Report
Brosius, Frank (2008)	2008	Annual Report
Brosius, Frank (2009)	2009	Annual Report
Brosius, Frank (2010)	2010	Annual Report
Brosius, Frank (2011)	2011	Annual Report

Publication	Submitted By	PubMed ID	Status
Year: 2017; Items: 2
Comparative RNA-Seq transcriptome analyses reveal distinct metabolic pathways in diabetic nerve and kidney disease. Hinder LM, Park M, Rumora AE, Hur J, Eichinger F, Pennathur S, Kretzler M, Brosius FC, Feldman EL Journal of cellular and molecular medicine, 2017	Hur, Junguk	28272773	Published
Podocyte-specific JAK2 overexpression worsens diabetic kidney disease in mice. Zhang H, Nair V, Saha J, Atkins KB, Hodgin JB, Saunders TL, Myers MG, Werner T, Kretzler M, Brosius FC Kidney international, 2017	Hodgin, Jeffrey	28554737	Published
Year: 2016; Items: 2
JAK inhibition in the treatment of diabetic kidney disease. Brosius FC, Tuttle KR, Kretzler M Diabetologia, 2016 (59), 1624 - 7	Kretzler, Matthias	27333885	Published
Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications. Sas KM, Kayampilly P, Byun J, Nair V, Hinder LM, Hur J, Zhang H, Lin C, Qi NR, Michailidis G, Groop PH, Nelson RG, Darshi M, Sharma K, Schelling JR, Sedor JR, Pop-Busui R, Weinberg JM, Soleimanpour SA, Abcouwer SF, Gardner TW, Burant CF, Feldman EL, Kretzler M, Brosius FC, Pennathur S JCI insight, 2016 (1), e86976	Abcouwer, Steven	27699244	Published
Year: 2014; Items: 2
Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, Muresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Saha J, Burke GW, Abel ED, Brosius FC, Fornoni A Diabetes, 2014 (63), 701 - 714	Fornoni, Alessia	24101677	Published
MicroRNA-21 in Glomerular Injury. Lai JY, Luo J, O'Connor C, Jing X, Nair V, Ju W, Randolph A, Ben-Dov IZ, Matar RN, Briskin D, Zavadil J, Nelson RG, Tuschl T, Brosius FC, Kretzler M, Bitzer M Journal of the American Society of Nephrology : JASN, 2014	Bitzer, Markus	25145934	Published
Year: 2013; Items: 4
Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli. Hodgin JB, Nair V, Zhang H, Randolph A, Harris RC, Nelson RG, Weil EJ, Cavalcoli JD, Patel JM, Brosius FC, Kretzler M Diabetes, 2013 (62), 299 - 308	Kretzler, Matthias	23139354	Published
New targets for treatment of diabetic nephropathy: what we have learned from animal models. Brosius FC, Alpers CE Current opinion in nephrology and hypertension, 2013 (22), 17 - 25	Alpers, Charles	23207723	Published
How to find a prognostic biomarker for progressive diabetic nephropathy. Brosius FC, Pennathur S Kidney international, 2013 (83), 996 - 998	Submitted Externally	23728003	Published
AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, Decleves AE, Andreyev A, Quach T, Ly S, Shekhtman G, Nguyen W, Chepetan A, Le TP, Wang L, Xu M, Paik KP, Fogo A, Viollet B, Murphy A, Brosius F, Naviaux RK, Sharma K The Journal of clinical investigation, 2013 (123), 4888 - 4899	Sharma, Kumar	24135141	Published
Year: 2012; Items: 2
Do we now have a prognostic biomarker for progressive diabetic nephropathy? Brosius FC, Saran R Journal of the American Society of Nephrology : JASN, 2012 (23), 376 - 377	Brosius, Frank	22323641	Published
Perspectives on systems biology applications in diabetic kidney disease. Komorowsky CV, Brosius FC, Pennathur S, Kretzler M Journal of cardiovascular translational research, 2012 (5), 491 - 508	Kretzler, Matthias	22733404	Published
Year: 2011; Items: 2
The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy. Kumar PA, Brosius FC, Menon RK Current diabetes reviews, 2011 (7), 50 - 55	Brosius, Frank	21067510	Published
GLUT1 enhances mTOR activity independently of TSC2 and AMPK. Buller CL, Heilig CW, Brosius FC American journal of physiology. Renal physiology, 2011 (301), F588 - F596	Brosius, Frank	21613414	Published
Year: 2010; Items: 8
The management of diabetic neuropathy in CKD. Pop-Busui R, Roberts L, Pennathur S, Kretzler M, Brosius FC, Feldman EL American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010 (55), 365 - 385	Feldman, Eva	20042258	Published
Abnormalities in signaling pathways in diabetic nephropathy. Brosius FC, Khoury CC, Buller CL, Chen S Expert review of endocrinology & metabolism, 2010 (5(1)), 51 - 64	Smithies, Oliver	20224802	Published
Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice. Zhang H, Schin M, Saha J, Burke K, Holzman LB, Filipiak W, Saunders T, Xiang M, Heilig CW, Brosius FC American journal of physiology. Renal physiology, 2010 (299), F91 - F98	Brosius, Frank	20375116	Published
Transgenic overexpression of GLUT1 in mouse glomeruli produces renal disease resembling diabetic glomerulosclerosis. Wang Y, Heilig K, Saunders T, Minto A, Deb DK, Chang A, Brosius F, Monteiro C, Heilig CW American journal of physiology. Renal physiology, 2010 (299), F99 - F111	Brosius, Frank	20375117	Published
Sex dimorphic actions of rosiglitazone in generalised peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-deficient mice. Duan SZ, Usher MG, Foley EL, Milstone DS, Brosius FC, Mortensen RM Diabetologia, 2010 (53), 1493 - 1505	Brosius, Frank	20401461	Published
A new pair of SOCS for diabetic nephropathy. Brosius FC, Banes-Berceli A Journal of the American Society of Nephrology : JASN, 2010 (21), 723 - 724	Brosius, Frank	20413610	Published
Susceptible mice: identifying a diabetic nephropathy disease locus using a murine model. Brosius FC Kidney international, 2010 (78), 431 - 432	Brosius, Frank	20706214	Published
Understanding kidney disease: toward the integration of regulatory networks across species. Ju W, Brosius FC Seminars in nephrology, 2010 (30), 512 - 519	Brosius, Frank	21044762	Published
Year: 2009; Items: 1
Mouse Models of Diabetic Nephropathy: A Midstream Analysis from the Diabetic Complications Consortium Frank C. Brosius IIIa, Charles E. Alpersb, Erwin P. Bottingerc, Matthew D. Breyerd, ThomasM. Coffmane, Susan B. Gurleye, Raymond C. Harrisf, Masao Kakokig, Matthias Kretzler, Edward H. Leiterh, Moshe Levii, Richard A. McIndoej, Kumar Sharmak, Oliver Smithiesg, Katalin Susztakl, Nobuyuki Takahashig, Takamune Takahashif Journal of the American Society of Nephrology : JASN, 2009 (20(12)), 2503 - 2512	Brosius, Frank	19729434	Published
Year: 2008; Items: 7
From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy. Qian Y, Feldman E, Pennathur S, Kretzler M, Brosius FC Diabetes, 2008 (57(6)), 1439 - 1445	Brosius, Frank	18511444	Published
Rosiglitazone Treatment Reduces Diabetic Neuropathy in STZ treated DBA/2J mice Timothy D Wiggin, Matthias Kretzler, Subramaniam Pennathur, Kelli A. Sullivan, Frank C Brosius, Eva L Feldman Endocrinology, 2008 (149(10)), 4928 - 4937	Feldman, Eva	18583417	Published
Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice. Blauwkamp MN, Yu J, Schin MA, Burke KA, Berry MJ, Carlson BA, Brosius FC, Koenig RJ BMC nephrology, 2008 (9), 7	Brosius, Frank	18647412	Published
Rosiglitazone reduces renal and plasma markers of oxidative injury and reverses urinary metabolite abnormalities in the amelioration of diabetic nephropathy Hongyu Zhang, Jharna Saha, MaryLee Schin, Jaeman Byun, Matthias Kretzler, Eva L. Feldman, David A. Weild, Subramaniam Pennathur, Frank C. Brosius III American journal of physiology. Renal physiology, 2008 (295(4)), F1071 - F1081	Brosius, Frank	18667486	Published
New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy. Brosius FC Reviews in endocrine & metabolic disorders, 2008 (9(4)), 245 - 254	Brosius, Frank	18726161	Published
Is the ER stressed out in diabetic kidney disease? Brosius FC, Kaufman RJ Journal of the American Society of Nephrology : JASN, 2008 (19), 2040 - 2042	Brosius, Frank	18842986	Published
Enhanced Expression of JAK-STAT Pathway Members in Human Diabetic Nephropathy Celine C. Berthier, PhD., Hongyu Zhang, M.D., MaryLee Schin, B.S., Anna Henger, PhD, Robert G. Nelson, M.D., PhD, Berne Yee, M.D., Anissa Boucherot, PhD., Christin Carter-Su, PhD., Lawrence S. Argetsinger, PhD., Maria Pia Rastaldi, M.D., Frank C. Brosius, M.D., Matthias Kretzler, M.D Diabetes, 2008 (Epub), 469 - 477	Brosius, Frank	19017763	Published
Year: 2007; Items: 1
Mouse models of diabetic neuropathy. Sullivan KA, Hayes JM, Wiggin TD, Backus C, Su Oh S, Lentz SI, Brosius F, Feldman EL Neurobiology of disease, 2007 (28(3)), 276 - 285	Feldman, Eva	17804249	Published
Year: 2006; Items: 2
Role for GLUT1 in diabetic glomerulosclerosis. Heilig CW, Brosius FC, Cunningham C Expert reviews in molecular medicine, 2006 (8(4)), 1	Brosius, Frank	16515729	Published
Reduction in Podocyte Density as a Pathologic Feature in Early Diabetic Nephropathy in Rodents: Prevention of by Lipoic Acid Treatment Brian Siu, Jharna Saha, William E. Smoyer, Kelli A. Sullivan, Frank C. Brosius III BMC nephrology [electronic resource], 2006 (7), 1 - 11	Brosius, Frank	16539708	Published
Year: 2005; Items: 3
Mouse Models of Diabetic Nephropathy MATTHEW D. BREYER, ERWIN BÖTTINGER, FRANK C. BROSIUS, III, THOMAS M. COFFMAN, RAYMOND C. HARRIS, CHARLES W. HEILIG, AND KUMAR SHARMA (FOR THE AMDCC) Journal of the American Society of Nephrology : JASN, 2005 (16), 27 - 45	Breyer, Matthew	15563560	Published
Glucose transporters in diabetic nephropathy. Brosius FC, Heilig CW Pediatric nephrology (Berlin, Germany), 2005 (20(4)), 447 - 451	Brosius, Frank	15717166	Published
Diabetic nephropathy: of mice and men. Breyer MD, Böttinger E, Brosius FC, Coffman TM, Fogo A, Harris RC, Heilig CW, Sharma K Advances in chronic kidney disease, 2005 (12(2)), 128 - 145	Sharma, Kumar	15822049	Published


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Title	Year	Type
Brosius, Frank (10/17/2005)	2005	Presentation
Brosius, Frank (10/19/2004)	2004	Presentation
Brosius, Frank (2006)	2006	Presentation
Brosius, Frank (2007)	2007	Presentation
Brosius, Frank (2009)	2009	Presentation
Brosius, Frank (3/23/2005)	2005	Presentation
Brosius, Frank (6/2004)	2004	Presentation
L) Systems Biology Workgroup	2010	Presentation

Title	Type	Version	Investigator(s)	Inactive
CATALASE	Phenotype Assay	1	Brosius, Frank Feldman, Eva	Active
Creatinine Companion Protocol Assay (Exocell)	Phenotype Assay	1	Brosius, Frank Leiter, Ed	Active
High Dose STZ Induction Protocol	Diabetes Induction	1	Brosius, Frank	Active
Mesangial Index Quantification	Phenotype Assay	1	Brosius, Frank	Active
Podocyte Count and Density Analysis	Phenotype Assay	1	Brosius, Frank	Active
Urine Albumin ELISA (Albuwell M kit)	Phenotype Assay	1	Brosius, Frank Leiter, Ed	Active

Name	Description
Nephropathy	The DiaComp Nephropathy Committee has the principal function of furthering the mission of the consortium with regard to diabetic kidney disease.

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