Edward Fisher

Personal Information
Title Professor
Expertise Cardiovascular
Institution New York University School of Medicine
Data Summary
Grants/SubContracts 1
Progress Reports 5
Presentations 2
Publications 13
Protocols 0
Committees 1

Creating Glucose Responsive Cardiovascular Complications
Grant Number: HL087945

Abstract: The PIs of this application have developed techniques for producing and studying atherosclerosis using funds from the first AMDCC program. Specifically, we have found that streptozotocin-treated mice develop increased atherosclerosis in the presence of a transgene for human aldose reductase (hAR). We have also noted that hearts from these mice have areas of cardiac apoptosis. In addition, we have developed novel methods to study atherosclerosis regression that can be applied to studies of lesions in control and diabetic mice. Aim 1 To create new mouse models of diabetic cardiovascular disease: We propose to create two new genetically altered mice. Aim 1a is to use the tet on system to allow expression of hAR in a time dependent manner. This system will allow us to test whether hAR expression in established lesions alters plaque morphology. These animals can also be used to produce tissue specific expression of hAR. Aim 1b is to produce mice with expression of hAR in cardiomyocytes. These mice, we hypothesize, will develop cardiomyopathy with diabetes. Aim 2 To study the development of vascular lesions in diabetic mice: Mild diabetes due to deficiency of Pdx1 or high fat diets did not alter atherosclerosis in Ldlr-/- mice. In addition, Pdx1 did not affect regression after transplant of arteries containing atherosclerosis. We will use two additional methods to generate hyperglycemia, Akita and high fat diets on the FVB background, in Ldlr-/- mice q hAR. Increased vascular disease in STZ-treated hAR mice could result from greater monocyte/macrophage accumulation in lesions, or could be secondary to a defect in lesion regression. Both processes will be studied in vivo and mechanistic information obtained by studying gene and protein expression.

Institution: New York University School of Medicine
550 First Avenue
New York, NY
Fiscal Year:2006
Project Start: 9/4/2006
Project End: 8/31/2011

Progress Reports

No funding program application progress reports found.

Annual Reports

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Title YearTypeOptions
Fisher, Edward (2007)
2007Annual Report
Fisher, Edward (2008)
2008Annual Report
Fisher, Edward (2009)
2009Annual Report
Fisher, Edward (2010)
2010Annual Report
Fisher, Edward (2011)
2011Annual Report

 PublicationAltmetricsSubmitted ByPubMed IDStatus

Year: 2015; Items: 1

Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice.
Willecke F, Yuan C, Oka K, Chan L, Hu Y, Barnhart S, Bornfeldt KE, Goldberg IJ, Fisher EA
PLoS ONE, 2015 (10), e0128996

Year: 2014; Items: 2

Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.
Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ, Murphy AJ
Cell Metabolism, 2014 (19), 821 - 835
Submitted Externally
Lipolysis, and Not Hepatic Lipogenesis, Is the Primary Modulator of Triglyceride Levels in Streptozotocin-Induced Diabetic Mice.
Willecke F, Scerbo D, Nagareddy P, Obunike JC, Barrett TJ, Abdillahi ML, Trent CM, Huggins LA, Fisher EA, Drosatos K, Goldberg IJ
Arteriosclerosis, thrombosis, and vascular biology, 2014 (35), 102 - 110

Year: 2013; Items: 2

ACAT inhibition reduces the progression of preexisting, advanced atherosclerotic mouse lesions without plaque or systemic toxicity.
Rong JX, Blachford C, Feig JE, Bander I, Mayne J, Kusunoki J, Miller C, Davis M, Wilson M, Dehn S, Thorp E, Tabas I, Taubman MB, Rudel LL, Fisher EA
Arteriosclerosis, thrombosis, and vascular biology, 2013 (33), 4 - 12
Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis.
Nagareddy PR, Murphy AJ, Stirzaker RA, Hu Y, Yu S, Miller RG, Ramkhelawon B, Distel E, Westerterp M, Huang LS, Schmidt AM, Orchard TJ, Fisher EA, Tall AR, Goldberg IJ
Cell Metabolism, 2013 (17), 695 - 708

Year: 2011; Items: 1

Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice.
Parathath S, Grauer L, Huang LS, Sanson M, Distel E, Goldberg IJ, Fisher EA
Diabetes, 2011 (60), 1759 - 1769

Year: 2009; Items: 1

The role of a murine transplantation model of atherosclerosis regression in drug discovery.
Feig JE, Quick JS, Fisher EA
Current opinion in investigational drugs (London, England : 2000), 2009 (10), 232 - 238

Year: 2007; Items: 3

Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI.
Amirbekian V, Lipinski MJ, Briley-Saebo KC, Amirbekian S, Aguinaldo JG, Weinreb DB, Vucic E, Frias JC, Hyafil F, Mani V, Fisher EA, Fayad ZA
Proceedings of the National Academy of Sciences of the United States of America, 2007 (104), 961 - 966
Submitted Externally
Non-invasive MRI of mouse models of atherosclerosis.
Weinreb DB, Aguinaldo JG, Feig JE, Fisher EA, Fayad ZA
NMR in biomedicine, 2007 (20), 256 - 264
Submitted Externally
Recipes for Creating Animal Models of Diabetic Cardiovascular Disease
Willa Hsueh, E. Dale Abel, Jan L. Breslow, Nobuyo Maeda, Richard C. Davis, Edward A. Fisher, Hayes Dansky, Donald A. McClain, Richard McIndoe, Momtaz K. Wassef, Cristina Rabadan-Diehl, Ira J. Goldberg
Circulation research, 2007 (100), 1415 - 1427

Year: 2006; Items: 1

Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice.
Trogan E, Feig JE, Dogan S, Rothblat GH, Angeli V, Tacke F, Randolph GJ, Fisher EA
Proceedings of the National Academy of Sciences of the United States of America, 2006 (103(10)), 3781 - 3786

Year: 2004; Items: 1

Serial studies of mouse atherosclerosis by in vivo magnetic resonance imaging detect lesion regression after correction of dyslipidemia.
Trogan E, Fayad ZA, Itskovich VV, Aguinaldo JG, Mani V, Fallon JT, Chereshnev I, Fisher EA
Arteriosclerosis, thrombosis, and vascular biology, 2004 (24), 1714 - 1719

Year: 2002; Items: 1

Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse.
Hofmann SM, Dong HJ, Li Z, Cai W, Altomonte J, Thung SN, Zeng F, Fisher EA, Vlassara H
Diabetes, 2002 (51), 2082 - 2089
Submitted Externally

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Title YearTypeOptions
Fisher, Edward (2007)
Fisher, Edward (2009)

No protocols found.

No experiments found.