||DBA/2J is a widely used inbred strain that is valuable in a
large number of research areas, including cardiovascular
biology, neurobiology, and sensorineural research. Its
characteristics are often contrasted with those of the
C57BL/6J inbred strain (Stock No. 000664). DBA/2J mice show
a low susceptibility to developing atherosclerotic aortic
lesions (20 to 350 um2 atherosclerotic aortic lesions
/aortic cross-section) following 14 weeks on an atherogenic
diet (1.25% cholesterol, 0.5% cholic acid and 15% fat). They
also exhibit high-frequency hearing loss beginning roughly
at the time of weaning/adolescence (between three to four
weeks of age) and becoming severe by two to three months of
age. The age related hearing loss 8 mutation arose
spontaneously in DBA/2J between 1951 and 1975. This strain
possesses three recessive alleles that cause progressive
cochlear pathology initially affecting the organ of Corti.
Decreasing anteroventral cochlear nucleus volume decreases
and neuron loss parallel the progression of peripheral
hearing loss. Young DBA/2J inbred mice are also susceptible
to audiogenic seizures due to the asp2 mutation, however,
this susceptibility decreases as animals reach adulthood.
There is high incidence of calcareous pericarditis, and
calcified lesions of the testes, tongue and skeletal muscle.
This strain is among the least responsive to
phytohemagglutinin (Heiniger et al., 1975).