Thomas Abell

Personal Information
Title Professor
Expertise Gastro-Intestinal (GI)
Institution University of Louisville
Data Summary
TypeCount
Grants/SubContracts 1
Progress Reports 1
Publications 7
Protocols 0
Committees 2

SubContract(s)


Autonomic Dysregulation and Enteric Nerve Changes in the Pathophysiology of Diabetic Gastroparesis.
Previous work on the pathophysiology of diabetic gastroparesis (DM Gp) has focused on a number of areas, primarily on blood sugar control (BSC), gastric emptying (GET), and autonomic functioning (ANS), with a more recent emphasis on electrograms (EGs) and full thickness biopsies (FTB). DM Gp can be viewed as representing a loss of the normal regulation of the systems measured by these areas, resulting in the pathophysiologic mechanisms leading to the clinical manifestations of the disorder of DM Gp. This application explores the pathophysiology of Diabetic Gastroparesis (DM Gp) and, in particular, dysregulation in autonomic and enteric mechanisms with the overall goal to construct a model of the pathophysiology of Diabetic Gastroparesis that delineates dysregulation of autonomic and enteric pathways. This protocol has 3 aims: First, to study any associations between gastric mucosal electrograms (mEG) and gastric mucosal neuronal density (MND) in clinical DM Gp patients. Second, to investigate mucosal electrograms and gastric mucosal neuronal density associations and compare them to measures of systemic autonomic function by heart rate variability (HRV) in consecutive DM Gp patients. Third, to compare mucosal electrograms, gastric mucosal neuronal density, and heart rate variability to established measures of serosal electrograms (sEG), gastric full thickness biopsies (FTB) and traditional autonomic function testing (ANS) in patients with symptoms of DM Gp. The overall goal of the study is to construct a model of the pathophysiology of Diabetic Gastroparesis that delineates dysregulation of autonomic and enteric pathways. Thus, this protocol allows an investigation of autonomic deregulation and enteric nerve changes in the pathophysiology of diabetic gastroparesis in three ways: first, by studying mucosal electrograms and gastric mucosal neuronal density, secondly, by comparing them to measures of systemic autonomic function by heart rate variability and thirdly, by comparing the electrograms, gastric mucosal neuronal density, and heart rate variability to established measures of serosal electrograms gastric full thickness biopsies and traditional autonomic function testing.


Progress Reports

Annual Reports

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 PublicationAltmetricsSubmitted ByPubMed IDStatus

Year: 2019; Items: 1

 
Gastroparesis syndromes: Response to electrical stimulation.
Abell TL, Kedar A, Stocker A, Beatty K, McElmurray L, Hughes M, Rashed H, Kennedy W, Wendelschafer-Crabb G, Yang X, Fraig M, Omer E, Miller E, Griswold M, Pinkston C
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2019, e13534
30706646
Published

Year: 2018; Items: 2

 
Islet Cell Associated Autoantibodies and C-Peptide Levels in Patients with Diabetes and Symptoms of Gastroparesis.
Siraj ES, Homko C, Wilson LA, May P, Rao AD, Calles J, Farrugia G, Hasler WL, Koch KL, Nguyen L, Snape WJ, Abell TL, Sarosiek I, McCallum RW, Pasricha PJ, Clarke J, Tonascia J, Hamilton F, Parkman HP
Frontiers in endocrinology, 2018 (9), 32
29487566
Published
 
Efficacy of Gastric Electrical Stimulation for Gastroparesis: US/European Comparison.
Burlen J, Runnels M, Mehta M, Andersson S, Ducrotte P, Gourcerol G, Lindberg G, Fullarton G, Abrahamsson H, Al-Juburi A, Lahr C, Rashed H, Abell T
Gastroenterology research, 2018 (11), 349 - 354
30344806
Published

Year: 2016; Items: 1

 
Measures of Autonomic Dysfunction in Diabetic and Idiopathic Gastroparesis.
Mohammad MK, Pepper DJ, Kedar A, Bhaijee F, Familoni B, Rashed H, Cutts T, Abell TL
Gastroenterology research, 2016 (9), 65 - 69
27785328
Published

Year: 2015; Items: 3

 
Loss of Interstitial Cells of Cajal and Patterns of Gastric Dysrhythmia in Patients With Chronic Unexplained Nausea and Vomiting.
Angeli TR, Cheng LK, Du P, Wang TH, Bernard CE, Vannucchi MG, Faussone-Pellegrini MS, Lahr C, Vather R, Windsor JA, Farrugia G, Abell TL, O'Grady G
Gastroenterology, 2015 (149), 56 - 66.e5
25863217
Published
 
Serum Catecholamines and Dysautonomia in Diabetic Gastroparesis and Liver Cirrhosis.
Aslam N, Kedar A, Nagarajarao HS, Reddy K, Rashed H, Cutts T, Riely C, Abell TL
The American journal of the medical sciences, 2015 (350), 81 - 86
26181082
Published
 
Outcomes and Factors Associated With Reduced Symptoms in Patients with Gastroparesis.
Pasricha PJ, Yates KP, Nguyen L, Clarke J, Abell TL, Farrugia G, Hasler WL, Koch KL, Snape WJ, McCallum RW, Sarosiek I, Tonascia J, Miriel LA, Lee L, Hamilton F, Parkman HP
Gastroenterology, 2015
26299414
Published

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No protocols found.

No experiments found.