| | Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts.Ock S, Lee WS, Kim HM, Park KS, Kim YK, Kook H, Park WJ, Lee TJ, Abel ED, Kim J Biochimica et biophysica acta, 2018 (1864), 1183 - 1191 | | | 29378301 | Published |
| | Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses.Wende AR, Kim J, Holland WL, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED American journal of physiology. Heart and circulatory physiology, 2017 (313), H1098 - H1108 | | | 28822962 | Published |
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| | GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration.Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV Nature neuroscience, 2015 (18), 521 - 530 | | Submitted Externally | 25730668 | Published |
| | Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy.Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, Muresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Saha J, Burke GW, Abel ED, Brosius FC, Fornoni A Diabetes, 2014 (63), 701 - 714 | | | 24101677 | Published |
| | | | Submitted Externally | 24375641 | Published |
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| | Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC Journal of immunology (Baltimore, Md. : 1950), 2014 (192), 3626 - 36 | | Submitted Externally | 24616478 | Published |
| | Maintaining PGC-1a expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function.Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014 (28), 3691 - 702 | | | 24776744 | Published |
| | The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC Cell Metabolism, 2014 (20), 61 - 72 | | Submitted Externally | 24930970 | Published |
| | Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED Molecular and cellular biology, 2014 (34), 3450 - 60 | | | 25002528 | Published |
| | Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.Liu T, Kishton RJ, Macintyre AN, Gerriets VA, Xiang H, Liu X, Abel ED, Rizzieri D, Locasale JW, Rathmell JC Cell death & disease, 2014 (5), e1470 | | Submitted Externally | 25321477 | Published |
| | | | Submitted Externally | 22522495 | Published |
| | | | Submitted Externally | 23180812 | Published |
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| | Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED PLoS ONE, 2013 (8), e54221 | | | 23342106 | Published |
| | Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms.Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina S Journal of molecular and cellular cardiology, 2013 (64), 20 - 29 | | Submitted Externally | 23994159 | Published |
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| | Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED The Journal of clinical investigation, 2013 (123), 5319 - 5333 | | | 24177427 | Published |
| | Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice.Li Y, Wende AR, Nunthakungwan O, Huang Y, Hu E, Jin H, Boudina S, Abel ED, Jalili T The FEBS journal, 2012 (279), 599 - 611 | | Submitted Externally | 22221582 | Published |
| | Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Litwin SE, Weimer BC, Abel ED Journal of molecular and cellular cardiology, 2012 (52), 1019 - 1026 | | | 22342406 | Published |
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| | Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity.Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED Endocrinology, 2012 (153), 2677 - 2688 | | | 22510273 | Published |
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| | UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice.Boudina S, Han YH, Pei S, Tidwell TJ, Henrie B, Tuinei J, Olsen C, Sena S, Abel ED Diabetes, 2012 (61), 3260 - 3269 | | | 22912419 | Published |
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| | Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload.Symons JD, Hu P, Yang Y, Wang X, Zhang QJ, Wende AR, Sloan CL, Sena S, Abel ED, Litwin SE American journal of physiology. Heart and circulatory physiology, 2011 (300), H374 - H381 | | | 20971769 | Published |
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| | Central Leptin Signaling Is Required to Normalize Myocardial Fatty Acid Oxidation Rates in Caloric-Restricted ob/ob Mice.Sloan C, Tuinei J, Nemetz K, Frandsen J, Soto J, Wride N, Sempokuya T, Alegria L, Bugger H, Abel ED Diabetes, 2011 (60), 1424 - 1434 | | | 21441440 | Published |
| | | | Submitted Externally | 21752958 | Published |
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| | | | | 20180026 | Published |
| | Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED, Komuro I The Journal of clinical investigation, 2010 (120), 1506 - 1514 | | | 20407209 | Published |
| | Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED Endocrinology, 2010 (151), 3536 - 3542 | | | 20501666 | Published |
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| | Aberrant water homeostasis detected by stable isotope analysis.O'Grady SP, Wende AR, Remien CH, Valenzuela LO, Enright LE, Chesson LA, Abel ED, Cerling TE, Ehleringer JR PLoS ONE, 2010 (5), e11699 | | Submitted Externally | 20657736 | Published |
| | An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart.Fang X, Palanivel R, Cresser J, Schram K, Ganguly R, Thong FS, Tuinei J, Xu A, Abel ED, Sweeney G American journal of physiology. Endocrinology and metabolism, 2010 (299), E721 - E729 | | Submitted Externally | 20739511 | Published |
| | PPARg-induced cardiolipotoxicity in mice is ameliorated by PPARa deficiency despite increases in fatty acid oxidation.Son NH, Yu S, Tuinei J, Arai K, Hamai H, Homma S, Shulman GI, Abel ED, Goldberg IJ The Journal of clinical investigation, 2010 (120), 3443 - 3454 | | | 20852389 | Published |
| | | | | 23646039 | Published |
| | Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding.Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED Cardiovascular research, 2009 (82), 351 - 360 | | | 19147655 | Published |
| | Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED Circulation, 2009 (119(9)), 1272 - 1283 | | | 19237663 | Published |
| | Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction.Sena S, Hu P, Zhang D, Wang X, Wayment B, Olsen C, Avelar E, Abel ED, Litwin SE. Journal of molecular and cellular cardiology, 2009 (46(6)), 910 - 918 | | | 19249310 | Published |
| | Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED Circulation research, 2009 (104), 1085 - 1094 | | | 19342603 | Published |
| | Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel ED Diabetes, 2009 (58(9)), 1986 - 1997 | | | 19542201 | Published |
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| | Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ Journal of lipid research, 2008 (49), 2101 - 2112 | | | 18515784 | Published |
| | Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED Diabetes, 2008 (57), 2924 - 2932 | | | 18678617 | Published |
| | Recipes for Creating Animal Models of Diabetic Cardiovascular DiseaseWilla Hsueh, E. Dale Abel, Jan L. Breslow, Nobuyo Maeda, Richard C. Davis, Edward A. Fisher, Hayes Dansky, Donald A. McClain, Richard McIndoe, Momtaz K. Wassef, Cristina Rabadan-Diehl, Ira J. Goldberg Circulation research, 2007 (100), 1415 - 1427 | | | 17525381 | Published |
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| | Mitochondrial energetics in the heart in obesity related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteinsSihem Boudina, Sandra Sena, Heather Theobald, Xiaoming Sheng, Jordan J. Wright, Xia Xuan Hu, Salwa Aziz, Josie I. Johnson, Heiko Bugger,Vlad G. Zaha and E. Dale Abel Diabetes, 2007 (56(10)), 2457 - 2466 | | | 17623815 | Published |
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| | Cardiac Hypertrophy Caused by Peroxisome Proliferator Activated Receptor-Gamma Agonist Treatment Occurs Independently of Changes in Myocardial Insulin SignalingSandra Sena, Isaac R. Rasmussen, Adam R. Wende, Alfred P. McQueen, Heather A. Theobald, Nicole Wilde, Renata Oliveira Pereira, Sheldon E. Litwin, Joel P. Berger, E. Dale Abel Endocrinology, 2007 (148(12)), 6047 - 6053 | | | 17823261 | Published |
| | A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED Cell Metabolism, 2007 (6), 294 - 306 | | | 17908558 | Published |
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| | Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A PLoS biology, 2006 (4), e369 | | Submitted Externally | 17090215 | Published |
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| | Reduced Cardiac Efficiency and Altered Substrate Metabolism Precedes the Onset of Hyperglycemia and Contractile Dysfunction in Two Mouse Models of Insulin Resistance and ObesityJonathan Buchanan, Pradip K. Mazumder, Ping Hu, Gopa Chakrabarti, Matthew W. Roberts, Ui Jeong Yun, Robert C. Cooksey, Sheldon E. Litwin, and E. Dale Abel Endocrinology, 2005 (146), 5341 - 5349 | | | 16141388 | Published |
| | Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary densityAlfred P. McQueen, Dongfang Zhang, Ping Hu, LeAnne Swenson, Ying Yang, Vlad G. Zaha, James L. Hoffman, Ui Jeong Yun, Gopa Chakrabarti, ZhengmingWang, Kurt H. Albertine, E. Dale Abel, Sheldon E. Litwin Journal of molecular and cellular cardiology, 2005 (39), 882 - 892 | | | 16216265 | Published |
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| | Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression.Belke DD, Betuing S, Tuttle MJ, Graveleau C, Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin SE, Taegtmeyer H, Severson D, Kahn CR, Abel ED. The Journal of clinical investigation, 2002 (109), 629 - 639 | | | 11877471 | Published |
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