Firouz Daneshgari

Personal Information
Title Professor
Expertise Uropathy
Institution Case Western Reserve
Data Summary
TypeCount
Grants/SubContracts 1
Progress Reports 8
Presentations 4
Publications 31
Protocols 2
Committees 1

Diabetic Uropathy Pathobiology Site
Grant Number: DK076162

Abstract: Diabetic Uropathy is a term for a range of debilitating urologic complications such as bladder dysfunction, urinary incontinence, urinary tract infection and sexual dysfunction, that are among the most common and costly, yet understudied complications of diabetes mellitus (DM), an incurable disease that affects at least 20 million people in the U.S. and is rising in prevalence with the rapidly rising prevalence of obesity. Therapeutic options for diabetic uropathy are inadequate and have not improved over the last 50 years. In response to RFA-DK-05-011, we propose to work with the Animal Models of Diabetic Complications Consortium's organizational structure to function as the 'Diabetic Uropathy Pathobiology Site" to participate in development of two novel mice models of diabetic uropathy and to investigate the mechanisms of the pathophysiology of diabetic bladder dysfunction in these animals. Based on the observed temporal effects of diabetes on the bladder function in small animals, we hypothesize that depletion of manganese superoxide dismutase (MnSOD) specifically in smooth muscle of adult mice will exacerbate accumulation of free radicals in smooth muscle during STZ-induced diabetes and accelerate the onset of the decompensated phase of diabetic bladder dysfunction. We hypothesize further that limiting depletion of MnSOD to arterial smooth muscle will have a lesser effect on STZ-induced diabetic bladder dysfunction by limiting exacerbation of STZ-induced free radical accumulation to the vasculature. Depletion of MnSOD selectively in total and arterial smooth muscle in the MnSODlox/lox, SMCreERT2 mice and MnSODlox/lox, ASM-CreERT2 mice, respectively, will be accomplished by administration of 4-hydroxytamoxifen to activate Cre recombinase expressed in the smooth muscle. The animals will be further treated with 4-hydroxytamoxifen treatment, and half of them will be injected with STZ to induce diabetes. The bladder function in the animals will be studied via four specific aims to examine: 1) the temporal alterations in the in-vivo bladder function by micturition habits and conscious cystometry; 2) the temporal course of morphological changes in diabetes-induced bladder hypertrophy; 3) temporal alterations in the contractile function of the detrusor muscle; 4) the temporal alterations in afferent and efferent autonomic pathways innervating the bladder. The Principal Investigator and the research team have a productive track record in being a part of the existing AMDCC since 2003 and have functioned well under the auspices of the NIH, and the Steering and External Advisory Committees of the AMDCC.


Institution: Case Western Reserve
10900 Euclid Ave
Cleveland, OH
Fiscal Year:2006
Department:MOLECULAR MEDICINE
Project Start: 9/30/2006
Project End: 8/31/2011
ICD: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Progress Reports

No funding program application progress reports found.

Annual Reports

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Daneshgari, Firouz (2004)
2004Annual Report
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Daneshgari, Firouz (2005)
2005Annual Report
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Daneshgari, Firouz (2006)
2006Annual Report
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Daneshgari, Firouz (2007)
2007Annual Report
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Daneshgari, Firouz (2008)
2008Annual Report
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Daneshgari, Firouz (2009)
2009Annual Report
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Daneshgari, Firouz (2010)
2010Annual Report
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Daneshgari, Firouz (2011)
2011Annual Report
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 PublicationAltmetricsSubmitted ByPubMed IDStatus

Year: 2018; Items: 1

 
Retinal angiotensin II and angiotensin-(1-7) response to hyperglycemia and an intervention with captopril.
Senanayake PD, Bonilha VL, W Peterson J, Yamada Y, Karnik SS, Daneshgari F, Brosnihan KB, Hollyfield JG
Journal of the renin-angiotensin-aldosterone system : JRAAS, 2018 (19)
30126320
Published

Year: 2015; Items: 3

 
Tissue specific dysregulated protein subnetworks in type 2 diabetic bladder urothelium and detrusor muscle.
Tomechko SE, Liu G, Tao M, Schlatzer D, Powell CT, Gupta S, Chance MR, Daneshgari F
Molecular & cellular proteomics : MCP, 2015
25573746
Published
 
Impaired cytokine expression, neutrophil infiltration, and bacterial clearance in response to urinary tract infection in diabetic mice.
Ozer A, Altuntas CZ, Bicer F, Izgi K, Hultgren SJ, Liu G, Daneshgari F
Pathogens and disease, 2015
25663347
Published
 
Advanced glycation end products facilitate bacterial adherence in urinary tract infection in diabetic mice.
Ozer A, Altuntas CZ, Izgi K, Bicer F, Hultgren SJ, Liu G, Daneshgari F
Pathogens and disease, 2015 (73)
25986378
Published

Year: 2014; Items: 1

 
Diabetic bladder dysfunction.
Liu G, Daneshgari F
Chinese medical journal, 2014 (127), 1357 - 1364
24709194
Published

Year: 2013; Items: 3

 
Roles of polyuria and hyperglycemia in bladder dysfunction in diabetes.
Xiao N, Wang Z, Huang Y, Daneshgari F, Liu G
The Journal of urology, 2013 (189), 1130 - 1136
22999997
Published
 
Impact of diabetes mellitus on bladder uroepithelial cells.
Hanna-Mitchell AT, Ruiz GW, Daneshgari F, Liu G, Apodaca G, Birder LA
American journal of physiology. Regulatory, integrative and comparative physiology, 2013 (304), R84 - R93
23174855
Published
 
Urethral striated muscle and extracellular matrix morphological characteristics among mildly diabetic pregnant rats: translational approach.
Piculo F, Marini G, Barbosa AM, Damasceno DC, Matheus SM, Felisbino SL, Daneshgari F, Rudge MV
International urogynecology journal, 2013 (25), 403 - 415
Submitted Externally
24043129
Published

Year: 2012; Items: 2

 
Calcineurin and Akt expression in hypertrophied bladder in STZ-induced diabetic rat.
Liu G, Li M, Daneshgari F
Experimental and molecular pathology, 2012 (92), 210 - 216
22305959
Published
 
Does diabetes mellitus-induced bladder remodeling affect lower urinary tract function? ICI-RS 2011.
Kirschner-Hermanns R, Daneshgari F, Vahabi B, Birder L, Oelke M, Chacko S
Neurourology and urodynamics, 2012 (31), 359 - 364
22415965
Published

Year: 2010; Items: 7

 
Voiding function in obese and type 2 diabetic female rats.
Gasbarro G, Lin DL, Vurbic D, Quisno A, Kinley B, Daneshgari F, Damaser MS
American journal of physiology. Renal physiology, 2010 (298), F72 - F77
19889955
Published
 
Animal models and their use in understanding lower urinary tract dysfunction.
Fry CH, Daneshgari F, Thor K, Drake M, Eccles R, Kanai AJ, Birder LA
Neurourology and urodynamics, 2010 (29), 603 - 608
20432320
Published
 
20554373
Published
 
Temporal morphological and functional impact of complete urinary diversion on the bladder: a model of bladder disuse in rats.
Liu G, Lin YH, Li M, Xiao N, Daneshgari F
The Journal of urology, 2010 (184), 2179 - 2185
20850838
Published
 
Pudendal nerve injury reduces urethral outlet resistance in diabetic rats
Pan HQ, Lin DL, Strauch C, Butler RS, Monnier VM, Daneshgari F, Damaser MS
American journal of physiology. Renal physiology, 2010 (299), F1443 - F1450
20881033
Published
 
Expression of monocyte chemotactic protein 3 following simulated birth trauma in a murine model of obesity
Vricella GJ, Tao M, Altuntas CZ, Liu G, Kavran M, Daneshgari F, Hijaz AK
Urology, 2010 (76), 1517.e12 - e17
20970834
Published
 
21087392
Published

Year: 2009; Items: 3

 
Urological complications of obesity and diabetes.
Daneshgari F, Brown JS, Kusek JW, Nyberg LM
The Journal of urology, 2009 (182), S1
19846132
Published
 
Diabetic bladder dysfunction: current translational knowledge.
Daneshgari F, Liu G, Birder L, Hanna-Mitchell AT, Chacko S
The Journal of urology, 2009 (182), S18 - S26
19846137
Published
 
Animal models of diabetic uropathy.
Daneshgari F, Leiter EH, Liu G, Reeder J
The Journal of urology, 2009 (182), S8 - 13
19846143
Published

Year: 2008; Items: 4

 
A mouse model of simulated birth trauma induced stress urinary incontinence.
Lin YH, Liu G, Daneshgari F
Neurourology and urodynamics, 2008 (27(4)), 353 - 358
17849481
Published
 
Efficacy of a novel device for assessment of autonomic sensory function in the rat bladder.
Abouassaly R, Liu G, Yamada Y, Ukimura O, Daneshgari F
The Journal of urology, 2008 (179), 1167 - 1172
18206176
Published
 
External urethral sphincter activity in diabetic rats.
Liu G, Lin YH, Yamada Y, Daneshgari F
Neurourology and urodynamics, 2008 (27), 429 - 434
18351620
Published
 
Bladder dysfunction in mice with experimental autoimmune encephalomyelitis.
Altuntas CZ, Daneshgari F, Liu G, Fabiyi A, Kavran M, Johnson JM, Gulen MF, Jaini R, Li X, Frenkl TL, Tuohy VK
Journal of neuroimmunology, 2008 (203(1)), 58 - 63
18703233
Published

Year: 2007; Items: 2

 
Diabetes slows the recovery from urinary incontinence due to simulated childbirth in female rats
Ja-Hong Kim, Xiao Huang, Guiming Liu, Courtenay Moore, James Bena, Margot S. Damaser and Firouz Daneshgari
American journal of physiology. Regulatory, integrative and comparative physiology, 2007 (293), R950 - R955
17491107
Published
 
Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice.
Liu G, Daneshgari F, Li M, Lin D, Lee U, Li T, Damaser MS
BJU international, 2007 (100(2)), 414 - 418
17555473
Published

Year: 2006; Items: 4

 
Temporal differences in bladder dysfunction caused by diabetes, diuresis, and treated diabetes in mice.
Daneshgari F, Huang X, Liu G, Bena J, Saffore L, Powell CT
American journal of physiology. Regulatory, integrative and comparative physiology, 2006 (290), R1728 - R1735
16439670
Published
 
Temporal diabetes- and diuresis-induced remodeling of the urinary bladder in the rat.
Liu G, Daneshgari F.
American journal of physiology. Regulatory, integrative and comparative physiology, 2006 (291), R837 - R843
16513765
Published
 
Effects of cold storage on the function and morphology of isolated urinary bladder in rat.
Liu G, Daneshgari F
Neurourology and urodynamics, 2006 (25(4)), 381 - 387
16710851
Published
 
Time dependent changes in diabetic cystopathy in rats include compensated and decompensated bladder function.
Daneshgari F, Liu G, Imrey PB
The Journal of urology, 2006 (176), 380 - 386
16753447
Published

Year: 2005; Items: 1

 
Alterations in neurogenically mediated contractile responses of urinary bladder in rats with diabetes.
Liu G, Daneshgari F
American journal of physiology. Renal physiology, 2005 (288), F1220 - F1226
15687244
Published

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Daneshgari, Firouz (2004)
2004Presentation
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Daneshgari, Firouz (2005)
2005Presentation
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Daneshgari, Firouz (2006)
2006Presentation
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Daneshgari, Firouz (2009)
2009Presentation
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No experiments found.